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Population pharmacokinetics of fluconazole in liver transplantation: implications for target attainment for infections with Candida albicans and non-albicans spp.

Pier Giorgio CojuttiManuela LuganoElda RighiGiorgio Della RoccaMatteo BassettiWilliam HopeFederico Pea
Published in: European journal of clinical pharmacology (2018)
Fluconazole dosages of 100-200 mg daily may ensure optimal PTA against C. albicans, C. parapsilosis, and C. tropicalis. Higher dosages are required against C. glabrata. Estimated creatinine clearance is not a reliable predictor of fluconazole clearance in LT patients.
Keyphrases
  • candida albicans
  • biofilm formation
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • prognostic factors
  • physical activity
  • patient reported outcomes
  • staphylococcus aureus