Jagged1 contained in MSC-derived small extracellular vesicles promotes squamous differentiation of cervical cancer by activating NOTCH pathway.

Weizhao LiXunzhi ZhangTianshun GaoLixiang LiuChi ZhangHuan YangJiayuan XieWei PanDavid Y B Deng Changlin Zhang Tian Li

Published in: Journal of cancer research and clinical oncology (2023)

MSC-sEV can activate the NOTCH pathway to promote squamous differentiation of CaSki cells and inhibit the growth proliferation and migration abilities of CaSki cells which may be a new mechanism for cervical cancer treatment.

Keyphrases

induced apoptosis
cell cycle arrest
high grade
signaling pathway
cell proliferation
low grade
endoplasmic reticulum stress
cell death