Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells.
Sarah B GittoJordan M BeardsleySai Preethi NakkinaJeremiah L OyerKathryn A ClineSally A LitherlandAlicja J CopikAmr S KhaledNa'im FanaianJ Pablo ArnolettiDeborah A AltomarePublished in: Cell communication and signaling : CCS (2020)
Chronic inflammation induces increased pancreatic cancer progression and immune cells such as eosinophils are attracted to areas of fibrosis. Results suggest that IL-5 in the pancreatic compartment stimulates increased IL-5Rα on ductal tumor cells to increase pancreatic tumor motility. Collectively, IL-5/IL-5Rα signaling in the mouse and human pancreatic tumors microenvironment is a novel mechanism to facilitate tumor progression. Additional file 1: Video Abstract.