A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3-Specific CAR T Cells in Solid Tumors.
Xinyuan LeiZhanpeng OuZhaohui YangJianglong ZhongYanliang ZhuJing TianJiannan WuHeran DengXinyu LinYu PengBowen LiLile HeZhiming TuWeixiong ChenQunxing LiNiu LiuHanqing ZhangZhangsong WangZezhen FangTeppei YamadaXiaobin LvTian TianGuokai PanFan WuLiping XiaoLizao ZhangTingting CaiXinhui WangBakhos A TannousJinsong LiFilippos KontosSoldano FerroneSong FanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Our results show that our novel strategy which combines SAHA and B7-H3.CAR T cells enhances their therapeutic efficacy with solid cancers and justify its translation to a clinical setting.