Continuous cuffless monitoring of arterial blood pressure via graphene bioimpedance tattoos.
Dmitry KireevKaan SelBassem IbrahimNeelotpala KumarAli AkbariRoozbeh JafariDeji AkinwandePublished in: Nature nanotechnology (2022)
Continuous monitoring of arterial blood pressure (BP) in non-clinical (ambulatory) settings is essential for understanding numerous health conditions, including cardiovascular diseases. Besides their importance in medical diagnosis, ambulatory BP monitoring platforms can advance disease correlation with individual behaviour, daily habits and lifestyle, potentially enabling analysis of root causes, prognosis and disease prevention. Although conventional ambulatory BP devices exist, they are uncomfortable, bulky and intrusive. Here we introduce a wearable continuous BP monitoring platform that is based on electrical bioimpedance and leverages atomically thin, self-adhesive, lightweight and unobtrusive graphene electronic tattoos as human bioelectronic interfaces. The graphene electronic tattoos are used to monitor arterial BP for >300 min, a period tenfold longer than reported in previous studies. The BP is recorded continuously and non-invasively, with an accuracy of 0.2 ± 4.5 mm Hg for diastolic pressures and 0.2 ± 5.8 mm Hg for systolic pressures, a performance equivalent to Grade A classification.
Keyphrases
- blood pressure
- hypertensive patients
- heart rate
- cardiovascular disease
- healthcare
- body composition
- physical activity
- metabolic syndrome
- left ventricular
- machine learning
- endothelial cells
- public health
- heart failure
- deep learning
- blood glucose
- type diabetes
- adipose tissue
- high throughput
- coronary artery disease
- climate change
- case control
- skeletal muscle
- living cells
- ejection fraction