Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma.
Anna BrandtBenjamin ThieleChristoph SchultheißEveline DaetwylerMascha BinderPublished in: Cancers (2023)
Tumors shed cell-free DNA (cfDNA) into the plasma. "Liquid biopsies" are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may be useful in patients with head and neck squamous cell carcinoma (HNSCC) due to genetic tumor heterogeneity and limitations in imaging sensitivity. However, there are technical challenges that need to be overcome for the widespread use of liquid biopsy in the clinical management of these patients. In this review, we discuss our current understanding of HNSCC genetics and the role of cfDNA genomic analyses as an emerging precision diagnostic tool.
Keyphrases
- circulating tumor
- end stage renal disease
- cell free
- copy number
- circulating tumor cells
- chronic kidney disease
- single cell
- ejection fraction
- ionic liquid
- newly diagnosed
- prognostic factors
- papillary thyroid
- high resolution
- ultrasound guided
- peritoneal dialysis
- genome wide
- patient reported outcomes
- mass spectrometry
- dna methylation
- squamous cell
- young adults
- fluorescence imaging