The Possible Protective Effects of Ondansetron and Tropisetron on Optic Nerve Crush Injury in Rats.

Maryam ShayanFaezeh EslamiAyda KhosraviAmir RashidianRazie Mohammad JafariSeyed Farzad MaroufiHasti Tashak GolroudbariAhmad Reza Dehpour

Published in: Drug research (2022)

Our findings indicate that cyclosporine, ondansetron, and tropisetron protect against ONC injury in rats, possibly via the suppression of apoptosis and modulation of calcineurin activity directly and via 5-HT3 receptors. Moreover, immunoblotting showed that tropisetron was more effective as opposed to ondansetron. Further studies are needed to evaluate the precise mechanism behind cyclosporine, ondansetron, and tropisetron activities.

Keyphrases

optic nerve
chemotherapy induced
optical coherence tomography
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell proliferation