Sex-based differences in severity and mortality in COVID-19.

Mustafa Alwani Aksam A Yassin Raed M Al-ZoubiOmar M AboumarzoukJoanne NettleshipDaniel KellyAhmad R Al-QudimatRidwan Shabsigh

Published in: Reviews in medical virology (2021)

The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS-CoV and MERS-CoV, and viral infections in general. Here, we discuss the sex-disaggregated epidemiological data for COVID-19 and highlight underlying differences that may explain the sexual dimorphism to help inform risk stratification strategies and therapeutic options.

Keyphrases

respiratory syndrome coronavirus
sars cov
coronavirus disease
cardiovascular events
risk factors
mental health
electronic health record
big data
coronary artery disease
data analysis