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S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells.

Yuki NakamuraHisataka IwataTakehito KuwayamaKoumei Shirasuna
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
We suggest that bovine OECs recognize an excessive increase in age-associated DAMPs, such as S100A8 and S100A9, and that these signals may contribute to chronic oviductal inflammation, resulting in infertility associated with oviductal dysfunction.
Keyphrases
  • oxidative stress
  • endothelial cells
  • weight gain
  • metabolic syndrome
  • polycystic ovary syndrome
  • body mass index
  • adipose tissue
  • skeletal muscle
  • drug induced