S100A8, which increases with age, induces cellular senescence-like changes in bovine oviduct epithelial cells.
Yuki NakamuraHisataka IwataTakehito KuwayamaKoumei ShirasunaPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
We suggest that bovine OECs recognize an excessive increase in age-associated DAMPs, such as S100A8 and S100A9, and that these signals may contribute to chronic oviductal inflammation, resulting in infertility associated with oviductal dysfunction.