Targeted deletion of nicotinamide adenine dinucleotide phosphate oxidase 4 from proximal tubules is dispensable for diabetic kidney disease development.

Vicki Thallas-BonkeSih Min TanRuna S LindblomMatthew SnelsonCesare GranataJay Chandra JhaKarly C SourrisAdrienne LaskowskiAnna WatsonMichel TaucIsabelle RuberaGuoping ZhengAjay M ShahDavid C H HarrisMahmoud H ElbatreekPhillip KantharidisMark E CooperKarin Jandeleit-DahmMelinda T Coughlan

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021)

Taken together, these results demonstrate that genetic deletion of Nox4 from the proximal tubules does not influence DKD development, indicating that Nox4 localization within this highly energetic compartment is dispensable for chronic kidney disease pathogenesis in the setting of diabetes.

Keyphrases

chronic kidney disease
type diabetes
cardiovascular disease
end stage renal disease
glycemic control
gene expression
copy number
metabolic syndrome
dna methylation
drug delivery
insulin resistance
weight loss