HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion.
Andrew NguyenDominique BrownRamya KrishnanDonald J BastinLi DengLan ChenOmar SalemScott R WalshJonathan L BramsonYonghong WanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Tumor burden-induced pathway changes can be reversed through epigenetic reprogramming, enabling the conversion from T-cell exhaustion to effector lineage differentiation.