Plasma proteome perturbation for CMV DNAemia in kidney transplantation.

Tara K SigdelPatrick BoadaMaggie KerwinPriyanka RashmiDavid GjertsonMaura RossettiSwastika SurDane MunarJames CiminoRichard AhnHarry PickeringSubha SenRajesh ParmarBenoit FatouHanno SteenJoanna SchaenmanSuphamai BunnapradistElaine F ReedMinnie M Sarwalnull null

Published in: PloS one (2023)

Plasma proteomic and transcriptional perturbations impacting humoral and innate immune pathways are observed during CMV infection and provide biomarkers for CMV disease prediction and resolution. Further studies to understand the clinical impact of these pathways can help in the formulation of different types and duration of anti-viral therapies for the management of CMV infection in the immunocompromised host.

Keyphrases

kidney transplantation
innate immune
immune response
sars cov
gene expression
transcription factor
oxidative stress
intensive care unit