GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation.
Leon A SokulskyBridie GogginsSimonne SherwinFiona EyersGerard E KaikoPhilip G BoardSimon KeelyMing YangPaul S FosterPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
We propose that GSTO1-1 is a novel negative regulator of TLR4-regulated M2 responses acting as an anti-inflammatory pathway. The discovery of a novel HIF-1α-induced eotaxin pathway identifies an unknown connection between hypoxia and the regulation of the severity of allergic inflammation in asthma.