PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

Makhala Michell Khammy Thomas DalsgaardPeter Hjørringgaard LarsenClaus Tornby ChristoffersenDorte ClausenLars Kyhn RasmussenLasse FolkersenMorten GrunnetJan KehlerChristian AalkjaerJacob Nielsen

Published in: British journal of pharmacology (2017)

Pde1a is the dominant PDE1 isoform present in VSMCs, and relaxation mediated by PDE1A inhibition is predominantly driven by enhanced cGMP signalling. These results imply that isoform-selective PDE1 inhibitors are powerful investigative tools allowing examination of physiological and pathological roles of PDE1 isoforms.

Keyphrases

nitric oxide
oxidative stress
single molecule
protein kinase
african american