A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest.
Simon MølstrømTroels Halfeld NielsenCarl-Henrik NordstrømAxel ForsseSøren MøllerSøren VenøDmitry MamaevTomas TencerÁsta TheódórsdóttirThomas KrøigårdJacob MøllerChristian HassagerJesper KjærgaardHenrik SchmidtPalle ToftPublished in: Critical care (London, England) (2023)
Among comatose patients resuscitated from OHCA, targeting a higher MAP 180 min after ROSC did not significantly improve cerebral energy metabolism within 96 h of post-resuscitation care. Patients with a poor clinical outcome exhibited significantly worse biochemical patterns, probably illustrating that insufficient tissue oxygenation and recirculation during the initial hours after ROSC were essential factors determining neurological outcome.
Keyphrases
- cardiac arrest
- blood pressure
- end stage renal disease
- clinical trial
- healthcare
- cardiopulmonary resuscitation
- double blind
- newly diagnosed
- phase iii
- chronic kidney disease
- ejection fraction
- study protocol
- palliative care
- prognostic factors
- cerebral ischemia
- phase ii
- subarachnoid hemorrhage
- type diabetes
- heart rate
- quality improvement
- white matter
- placebo controlled
- multiple sclerosis
- blood brain barrier
- blood glucose
- metabolic syndrome
- pain management
- hypertensive patients
- chronic pain
- adipose tissue
- anaerobic digestion
- affordable care act
- health insurance
- patient reported outcomes