No seroconversion in a retrospective study analyzing QuantiFERON TB-gold testing in pediatric psoriasis and hidradenitis suppurativa patients taking biologic therapy at an academic center in New York City.
Apostolos KatsiaunisJade ConwayShari R LipnerPublished in: Pediatric dermatology (2024)
Guidelines are inconsistent regarding annual QuantiFERON® TB Gold (QFT) tests in children taking biologics for dermatological conditions, and there is limited research on seroconversion, especially in regions with high tuberculosis (TB) prevalence. A retrospective review of pediatric patients taking biologic treatment for psoriasis or hidradenitis suppurativa (HS) who had one baseline and at least one follow-up QFT test was conducted to assess for seroconversion during treatment. Thirty-two patients were included, with no instances of seroconversion. These findings suggest that routine annual TB rescreening for pediatric patients taking biologic therapy for dermatologic conditions may not be necessary without additional TB exposure risks or symptomatology.
Keyphrases
- mycobacterium tuberculosis
- hidradenitis suppurativa
- end stage renal disease
- rheumatoid arthritis
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- stem cells
- risk factors
- young adults
- clinical practice
- pulmonary tuberculosis
- hepatitis c virus
- climate change
- human health
- smoking cessation
- combination therapy
- electronic health record