A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice.

Keitetsu Kure Hiroki Sato Jun-Ichi SuzukiAkiko ItaiNorio Aoyama Yuichi Izumi

Published in: Journal of periodontal research (2018)

IMD-0354 regulated bone resorption by ligature-induced periodontitis, and it is suggested that the inhibition of IKK via down-regulation of NF kappa-B may provide periodontal patients with an effective approach to prevent or suppress the disease.

Keyphrases

bone loss
high glucose
diabetic rats
nuclear factor
signaling pathway
oxidative stress
drug induced
type diabetes
bone mineral density
endothelial cells
transcription factor
pi k akt
body composition
insulin resistance
toll like receptor
cell proliferation