Spatial UBE2N protein expression indicates genomic instability in colorectal cancers.

Timo GemollElena MirollOliver KleinAnnette LischkaMurat EravciChristoph ThornsJens K Habermann

Published in: BMC cancer (2019)

The results showed that FFPE protein expression profiling of surgically resected CRC tissue extracts by MALDI-TOF MS has potential value for improved molecular classification. Particularly, the protein expression of UBE2N was validated in an independent clinical cohort to distinguish euploid from aneuploid CRCs.

Keyphrases

mass spectrometry
machine learning
deep learning
genome wide
lymph node
copy number
protein protein
amino acid
human health
prognostic factors
genome wide identification
dna methylation
single molecule
gene expression
transcription factor
climate change
young adults