The association between a carrier state of FMR1 premutation and numeric sex chromosome variations.

Mira MalcovOphir BlicksteinDana Brabbing-GoldsteinAdi RechesYael KalmaYuval FouksFoad AzemYoni Cohen

Published in: Journal of assisted reproduction and genetics (2023)

Although carriers of FMR1 premutation exhibit signs of reduced ovarian response, it does not seem to affect the rate of numeric sex chromosomal variation compared to women undergoing PGT-M for other indications. This suggests that the mechanism for chromosomal number aberrations in women at advanced maternal age are different to those FMR1 premutation carriers with poor ovarian reserve.

Keyphrases

copy number
pregnancy outcomes
polycystic ovary syndrome
cervical cancer screening
breast cancer risk
pregnant women
insulin resistance
birth weight
body mass index
metabolic syndrome
adipose tissue
gestational age