A comparative analysis of chromatin accessibility in cattle, pig, and mouse tissues.

Michelle M HalsteadColin KernPerot SaelaoYing WangGanrea ChanthavixayJuan F MedranoAlison L Van EenennaamIan KorfChristopher K TuggleCatherine W ErnstHuaijun ZhouPablo Juan Ross

Published in: BMC genomics (2020)

The lack of conserved accessibility at distal elements is consistent with rapid evolution of enhancers, and further emphasizes the need to annotate regulatory elements in individual species, rather than inferring elements based on homology. This atlas of chromatin accessibility in cattle and pig constitutes a substantial step towards annotating livestock genomes and dissecting the regulatory link between genome and phenome.

Keyphrases

transcription factor
gene expression
genome wide
dna damage
single cell
minimally invasive
oxidative stress