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Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation.

Gareth S D PurvisMassimo CollinoHaidee Aranda-TavioFausto ChiazzaCaroline E O'RiordanLynda ZeboudjShireen MohammadDebora CollottaRoberta VertaNicolas E S GuisotPeter BunyardMagdi M YaqoobDavid R GreavesChristoph Thiemermann
Published in: British journal of pharmacology (2020)
We provide "proof of concept" evidence that BTK is a novel therapeutic target for the treatment of diet-induced metabolic inflammation and ibrutinib may be a candidate for drug repurposing as an anti-inflammatory agent for the treatment of metabolic inflammation in T2D and microvascular disease.
Keyphrases
  • oxidative stress
  • nlrp inflammasome
  • anti inflammatory
  • adipose tissue
  • tyrosine kinase
  • immune response
  • lps induced
  • inflammatory response