Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.
Rana M El-MasryHanan H KadryAzza T TaherSahar M Abou-SeriPublished in: Molecules (Basel, Switzerland) (2022)
The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design, synthesis, and the study of their potential activity towards a variety of diseases, including microbial and viral infections, cancer, diabetes, pain, and inflammation. This work is an up-to-date comparative study that identifies the differences between 1,3,4-thiadiazoles and 1,3,4-oxadiazoles concerning their methods of synthesis from different classes of starting compounds under various reaction conditions, as well as their biological activities and structure-activity relationship.
Keyphrases
- structure activity relationship
- type diabetes
- papillary thyroid
- chronic pain
- oxidative stress
- cardiovascular disease
- microbial community
- sars cov
- pain management
- genome wide
- klebsiella pneumoniae
- gene expression
- squamous cell carcinoma
- emergency department
- spinal cord injury
- pseudomonas aeruginosa
- drug resistant
- adipose tissue
- lymph node metastasis
- multidrug resistant
- postoperative pain