Exploring proteomic plasma biomarkers in eosinophilic and neutrophilic asthma.
Maura KereSusanna KlevebroNatalia Hernandez-PachecoMaria ÖdlingSandra EkströmIda MogensenChrister JanssonLena PalmbergMarianne van HageAntonios GeorgelisAnna BergströmInger KullErik MelénSophia BjörkanderPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2022)
Eosinophilic asthma was associated with a clear clinical phenotype. With our definitions, we identified MMP10 as a possible plasma biomarker for eosinophilic asthma and CCL4 was linked to neutrophilic asthma. These proteins should be evaluated further in clinical settings and using sputum granulocytes to define the asthma endotypes.