Acute respiratory distress syndrome (ARDS) remains to pose a high morbidity and mortality without any targeted therapies. Sedation, usually given intravenously, is an important part of clinical practice in intensive care unit (ICU), and the effect of sedatives on patients' outcomes has been studied intensively. Although volatile anesthetics are not routine sedatives in ICU, preclinical and clinical studies suggested their potential benefit in pulmonary pathophysiology. This review will summarize the current knowledge of ARDS and the role of volatile anesthetic sedation in this setting from both clinical and mechanistic standpoints. In addition, we will review the infrastructure to use volatile anesthetics.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- intensive care unit
- clinical practice
- gas chromatography
- end stage renal disease
- ejection fraction
- newly diagnosed
- healthcare
- mass spectrometry
- pulmonary hypertension
- stem cells
- metabolic syndrome
- skeletal muscle
- mesenchymal stem cells
- human health
- simultaneous determination