A new butenolide with antifungal activity from solid co-cultivation of Irpex lacteus and Nigrospora oryzae .

Ya-Mei WuXue-Qiong YangJing-Xin ChenTing WangTai-Ran LiFan-Rong LiaoRun-Tong LiuXue-Qiong Yang Zhong-Tao Ding

Published in: Natural product research (2022)

A new antifungal butenolide irperide ( 1 ) along with five known compounds were isolated from the co-culture of endophyte Irpex lacteus and pathogenic Nigrospora oryzae . The structure of 1 , including the absolute configuration, was elucidated by analysis of NMR, HR-ESI-MS data and ECD spectra. Compounds 1 , 4 and 6 exhibited significant antifungal activity against Aspergillus fumigatus , with MIC values of 1, 2 and 1 μg/mL, respectively.

Keyphrases

ms ms
mass spectrometry
magnetic resonance
high resolution
candida albicans
electronic health record
big data
solid state
density functional theory