Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model.
Milena SimovicMichiel BolkesteinMahmoud MoustafaJohn K L WongVerena KörberSarah BenedettoUmar KhalidHannah Sophia SchreiberManfred JugoldAndrey KorshunovDaniel HübschmannNorman MackStephan BronsPei-Chi WeiMichael O BreckwoldtSabine HeilandMartin BendszusJürgen DebusThomas HöferMarc ZapatkaMarcel KoolStefan M PfisterAmir AbdollahiAurélie ErnstPublished in: Neuro-oncology (2022)
The high efficacy and favorable toxicity profile of carbon ions warrants further investigation in primary medulloblastomas with chromothripsis. Postradiotherapy relapsed medulloblastomas exhibit relative resistance compared to treatment-naïve tumors, calling for exploration of multimodal strategies.
Keyphrases
- mouse model
- acute lymphoblastic leukemia
- early stage
- acute myeloid leukemia
- oxidative stress
- diffuse large b cell lymphoma
- radiation therapy
- locally advanced
- multiple myeloma
- radiation induced
- squamous cell carcinoma
- pain management
- combination therapy
- rectal cancer
- aqueous solution
- smoking cessation
- water soluble
- oxide nanoparticles