Exogenous fibroblast growth factor 1 ameliorates diabetes-induced cognitive decline via coordinately regulating PI3K/AKT signaling and PERK signaling.
Yanqing WuChengbiao WuLibing YeBeini WangYuan YuanYaqian LiuPeipei ZhengJun XiongYiyang LiTing JiangXiaokun LiZhou-Guang WangPublished in: Cell communication and signaling : CCS (2020)
We conclude that FGF1 exerts its neuroprotective role and normalizing hyperglycemia effect, consequently ameliorates DICD, implying FGF1 holds a great promise to develop a new treatment for DICD. Video abstract.
Keyphrases
- cognitive decline
- pi k akt
- signaling pathway
- mild cognitive impairment
- diabetic rats
- cell proliferation
- cell cycle arrest
- type diabetes
- mouse model
- cardiovascular disease
- high glucose
- endoplasmic reticulum stress
- oxidative stress
- drug induced
- glycemic control
- cell death
- big data
- metabolic syndrome
- skeletal muscle
- smoking cessation
- subarachnoid hemorrhage