Motor Cortical Network Excitability in Parkinson's Disease.

Giorgio LeodoriMaria Ilenia De BartoloAndrea GuerraAndrea FabbriniLorenzo RocchiAnna LatorreGiulia PaparellaDaniele BelvisiAntonella ConteKailash P Bhatia John C Rothwell Alfredo Berardelli

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Changes in M1 P30 and pre-SMA N40 in PD suggest that M1 excitability is reduced on both sides, whereas pre-SMA excitability is increased. The effect of dopaminergic therapy and the clinical correlation suggest that these cortical changes may reflect abnormal basal ganglia-thalamocortical activity. TMS electroencephalography provides novel insight into motor cortical network changes related to the pathophysiology of PD. © 2022 International Parkinson and Movement Disorder Society.

Keyphrases

transcranial direct current stimulation
stem cells
working memory
bone marrow
mesenchymal stem cells
smoking cessation
replacement therapy