The dose-dependent effect of estrogen on bone mineral density in trans girls.
Lidewij Sophia BoogersMaria Anna Theodora Catharina van der LoosChantal Maria WiepjesAdrianus Sarinus Paulus van TrotsenburgMartin den HeijerSabine Elisabeth HannemaPublished in: European journal of endocrinology (2023)
Higher estrogen dosage is associated with a greater increase in lumbar spine BMD Z-scores. Increasing dosage up to 2mg estradiol is insufficient to optimize BMD and approximately 4 mg may be required for adequate serum concentrations.