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Oral glucocorticoid use and osteonecrosis in children and adults with chronic inflammatory diseases: a population-based cohort study.

Daniel B HortonKevin HaynesMichelle R DenburgMihir M ThackerCarlos D RoseMary E PuttMary B LeonardBrian L Strom
Published in: BMJ open (2017)
Glucocorticoid use was clearly associated with osteonecrosis in a dose-related fashion in adults, especially young adults, but this risk was not detectable in children. The absolute risk of glucocorticoid-associated osteonecrosis in the general paediatric population and in adults taking low glucocorticoid doses is at most extremely small.
Keyphrases
  • young adults
  • emergency department
  • intensive care unit
  • oxidative stress
  • childhood cancer