Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration.

Julia E M van Dommelen Heleen Grootjans Esther V Uijtendaal Dieuwertje Ruigrok Bart Luijk Matthijs van Luin Wouter Bult Dylan W de Lange Nuray Kusadasi Joep M Droogh Antoine C G Egberts Erik Alfons Maria Verschuuren Maaike A Sikma

Published in: Clinical pharmacokinetics (2024)

Administering tacrolimus orally directly after LuTx leads to a higher variability in blood concentrations compared to intravenous administration. There was no difference in the occurrence of AKI or transplant rejection.

Keyphrases

high dose
acute kidney injury
risk assessment
extracorporeal membrane oxygenation
low dose