Concurrent thoracic mesothelioma and thyroid C-cell adenoma with amyloid deposition in an aged horse.
Jessica S FortinAngela B RoyalKeiichi KurokiPublished in: Veterinary medicine and science (2017)
A 21-year-old American Saddlebred mare died with a history of weight loss and breathing difficulties of 1 month duration. Post-mortem examination revealed a copious pleural effusion with multifocal to coalescing numerous white to grey nodular masses on the serosal surface of the pericardium, lungs and thoracic cavity. In addition, the left thyroid gland was markedly enlarged. A thoracic mesothelioma and C-cell adenoma with amyloid deposits of the left thyroid gland were diagnosed by histopathology and confirmed by immunohistochemistry employing antibodies against cytokeratin (CK), vimentin and calcitonin. Amyloid deposits in the thyroid tumour were confirmed by Congo red staining with apple-green birefringence under polarized light. Mesothelioma remains an uncommon neoplasm encountered in aged horses. Discussion includes the diagnostic challenge of differentiating carcinomatosis from mesothelioma by histology and differentiating reactive and neoplastic mesothelial cells by cytology.
Keyphrases
- single cell
- spinal cord
- weight loss
- induced apoptosis
- cell therapy
- contrast enhanced
- fine needle aspiration
- bariatric surgery
- stem cells
- high grade
- magnetic resonance imaging
- roux en y gastric bypass
- low grade
- white matter
- radiation therapy
- endoplasmic reticulum stress
- oxidative stress
- cell proliferation
- bone marrow
- insulin resistance
- skeletal muscle
- endothelial cells
- contrast enhanced ultrasound