Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy.

Linlin YangChangxian ShenCory J PettitTianyun LiAndrew J HuEric D MillerJunran ZhangSteven H LinTerence M Williams

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Abrogation of G2-M checkpoint by targeting Wee1 kinase with AZD1775 sensitizes esophageal cancer cells to radiotherapy in vitro and in mouse xenografts. Our findings suggest that inhibition of Wee1 by AZD1775 is an effective strategy for radiosensitization in esophageal cancer and warrants clinical testing.

Keyphrases

early stage
locally advanced
radiation induced
radiation therapy
induced apoptosis
dna damage
cell cycle
rectal cancer
protein kinase