Interaction of interictal epileptiform activity with sleep spindles is associated with cognitive deficits and adverse surgical outcome in pediatric focal epilepsy.
Han YuWoojoong KimDavid K ParkJi Hoon PhiByung Chan LimJong-Hee ChaeSeung-Ki KimKi Joong KimFrank A ProvenzanoDion KhodagholyJennifer N GelinasPublished in: Epilepsia (2023)
Our findings identify pathologic large-scale oscillatory coupling patterns in the immature brain. These results suggest that such intercortical interactions could predict risk for adverse neurocognitive and surgical outcomes, with the potential to serve as novel therapeutic targets to restore physiologic development.
Keyphrases
- neoadjuvant chemotherapy
- resting state
- high frequency
- physical activity
- white matter
- bipolar disorder
- adverse drug
- temporal lobe epilepsy
- room temperature
- functional connectivity
- locally advanced
- human health
- emergency department
- risk assessment
- radiation therapy
- young adults
- multiple sclerosis
- subarachnoid hemorrhage