Effect of perioperative intravenous ibuprofen versus acetaminophen on postoperative opioid consumption and pain after general anesthesia: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.

Sung Hye KimHyun KangIn-Jung JunHye Won ParkByung Hoon YooYun-Hee LimKye-Min Kim

Published in: Korean journal of anesthesiology (2024)

Perioperative IV ibuprofen reduced 24 h opioid consumption and pain severity up to 12 h postoperatively compared to acetaminophen. Additional research is required to assess pain intensity beyond 12 h and side effects.

Keyphrases

chronic pain
pain management
patients undergoing
neuropathic pain
cardiac surgery
postoperative pain
clinical trial
liver injury
high dose
high intensity
low dose
double blind