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Red blood cell alloimmunization in sickle cell disease: assessment of transfusion protocols during two time periods.

Sally A Campbell-LeeKristina GvozdjanK Mia ChoiYi-Fan ChenSantosh L SarafLewis L HsuVictor R GordeukRonald G StraussDarrell J Triulzi
Published in: Transfusion (2018)
The prevalence of initial and subsequent RBC alloimmunization in Period 2 was lower than that in Period 1; however, overall prevalence remained high. We recommend leukoreduced, hemoglobin S-negative Rh and Kell PAM RBCs for transfusion of patients with SCD. Component and recipient factors affecting alloimmunization should be studied further.
Keyphrases
  • sickle cell disease
  • red blood cell
  • risk factors
  • acute kidney injury