Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study.

Andre F S AmaralMedea ImbodenMatthias WielscherFaisal I RezwanCosetta MinelliJudith Garcia-AymerichGabriela P PeraltaJuha AuvinenAyoung JeongEmmanuel SchaffnerAnna Beckmeyer-BorowkoJohn W HollowayMarjo-Riitta JarvelinNicole M Probst-HenschDeborah L Jarvisnull null

Published in: BMC pulmonary medicine (2020)

To our knowledge, this is the first paper to report the use of a two-step MR approach to assess the role of DNA methylation in mediating the effect of a non-genetic factor on lung function. Our findings do not support a mediating effect of DNA methylation in the association of lung function with BMI.

Keyphrases

lung function
dna methylation
genome wide
body mass index
cystic fibrosis
chronic obstructive pulmonary disease
air pollution
gene expression
copy number
weight gain
healthcare
magnetic resonance
physical activity
contrast enhanced