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Differential Impact of Smoking on Methylome and Transcriptome in Crohn's Disease and Ulcerative Colitis.

Qi Yan AngDamian PlichtaSean KimIris Hyun-A KimSadie GregoryYan XiaHelena LauRamnik XavierAshwin N Ananthakrishnan
Published in: Inflammatory bowel diseases (2023)
Our findings suggest both common and differential effects of cigarette smoking on CD and UC. Paneth cell dysfunction may mediate adverse impact of smoking on CD. Bile acid and oxidative stress pathways may be relevant for the differential effect of smoking on CD and UC.
Keyphrases
  • oxidative stress
  • smoking cessation
  • single cell
  • ulcerative colitis
  • dna damage
  • rna seq
  • cell therapy
  • emergency department
  • bone marrow
  • mesenchymal stem cells
  • signaling pathway
  • adverse drug