Association of Sleep Duration and Change Over Time With Imaging Biomarkers of Cerebrovascular, Amyloid, Tau, and Neurodegenerative Pathology.
Andrée-Ann BarilDaniel J KojisJayanadra J HimaliCharles S DecarliErlan SanchezKeith A JohnsonGeorges Ei FakhriEmma ThibaultStephanie R YiallourouDibya HimaliMarina G CavuotoMatthew P PaseAlexa S BeiserSudha SeshadriPublished in: Neurology (2023)
Longer self-reported sleep duration over time was associated with neuroimaging biomarkers of cerebrovascular pathology as evidenced by higher WMH burden and FW fraction. A longer sleep duration extending over time may be an early change in the neurodegenerative trajectory.