Concept and application of the probability of pharmacological success (PoPS) as a decision tool in drug development: a position paper.

Chao ChenXuan ZhouSilvia Maria LavezziUsman ArshadRaman Sharma

Published in: Journal of translational medicine (2023)

The PoPS is a powerful evidence-based framework to formally capture multiple uncertainties into a single probability term for assessing benefit-risk ratio. In GSK, it is now expected for governance review at all early-phase decision gates.

Keyphrases

decision making
preterm infants
signaling pathway
pi k akt
gestational age
public health
cell proliferation
preterm birth