Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy.

Vipin Shankar ChelakkotJayoti SomEma YoshiokaChantel P RiceSuzette G RutihindaKensuke Hirasawa

Published in: British journal of cancer (2019)

We demonstrate a novel strategy to promote 5-ALA-PDT efficacy by targeting a cell signalling pathway regulating its sensitivity. This preclinical study provides a strong basis for utilising MEK inhibitors, which are approved for treating cancers, to enhance 5-ALA-PDT efficacy in the clinic.

Keyphrases

photodynamic therapy
fluorescence imaging
primary care
stem cells
young adults
signaling pathway