Brain cholesterol metabolism and Parkinson's disease.

Xuemei HuangNicholas W SterlingGuangwei DuDongxiao SunChristina StetterLan KongYusheng ZhuJeffery NeighborsMechelle M LewisHonglei ChenRaymond J HohlRichard B Mailman

Published in: Movement disorders : official journal of the Movement Disorder Society (2019)

Results indicate that plasma (S)24-OH-cholesterol (possibly reflecting brain cholesterol metabolism) is inversely linked to PD, is relatively stable over time, and may serve as a new biomarker for PD. Further investigation is necessary to determine the mechanistic and clinical implications. © 2019 International Parkinson and Movement Disorder Society.

Keyphrases

low density lipoprotein
resting state
white matter
functional connectivity
cerebral ischemia
multiple sclerosis
brain injury
blood brain barrier
subarachnoid hemorrhage