Brain cholesterol metabolism and Parkinson's disease.
Xuemei HuangNicholas W SterlingGuangwei DuDongxiao SunChristina StetterLan KongYusheng ZhuJeffery NeighborsMechelle M LewisHonglei ChenRaymond J HohlRichard B MailmanPublished in: Movement disorders : official journal of the Movement Disorder Society (2019)
Results indicate that plasma (S)24-OH-cholesterol (possibly reflecting brain cholesterol metabolism) is inversely linked to PD, is relatively stable over time, and may serve as a new biomarker for PD. Further investigation is necessary to determine the mechanistic and clinical implications. © 2019 International Parkinson and Movement Disorder Society.