Protective Effects of Oridonin on Acute Liver Injury via Impeding Posttranslational Modifications of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) in the Toll-Like Receptor 4 (TLR4) Signaling Pathway.
Min ShiYilin DengHeguo YuLing XuCuicui ShiJiong ChenGuangming LiYi-Qi DuYu-Gang WangPublished in: Mediators of inflammation (2019)
Our study revealed that the protective effects of oridonin on LPS/D-Gal-induced ALI mediated by inhibition of the PTMs of IRAK4, including phosphorylation of T345/S346 and acetylation of K34.
Keyphrases
- toll like receptor
- drug induced
- liver injury
- inflammatory response
- nuclear factor
- signaling pathway
- immune response
- protein kinase
- epithelial mesenchymal transition
- pi k akt
- liver failure
- anti inflammatory
- induced apoptosis
- single cell
- diabetic rats
- oxidative stress
- hepatitis b virus
- endoplasmic reticulum stress
- mechanical ventilation