Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline.

Jiang ChenZhi ZhangYing LiuLili HuangYi LiuDan YangXinyu BaoPinyi LiuYuhan GeQingqing LiXin ShuLushan XuYun Stone ShiXiao-Lei ZhuYun Xu

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Nr4a1 is reduced in PBMCs and CA1 PyrNs with aging. Nr4a1 ablation in CA1 PyrNs impaired cognition and excitatory synaptic function. Nr4a1 overexpression in CA1 PyrNs ameliorated cognitive impairment of aged mice. Nr4a1 bound to TrkB promoter to enhance transcription. Blocking TrkB function compromised Nr4a1-induced cognitive improvement.

Keyphrases

cognitive decline
mild cognitive impairment
cognitive impairment
transcription factor
gene expression
protein kinase
type diabetes
metabolic syndrome
endothelial cells
radiofrequency ablation