Aortic valve calcification and myocardial fibrosis determine outcome following transcatheter aortic valve replacement.
Ruben EvertzSebastian HubBo Eric BeuthnerSören J BackhausTorben LangeAlexander SchulzKarl ToischerTim SeidlerStephan von HaehlingMiriam PulsJohannes T KowallickElisabeth M ZeisbergGerd HasenfußAndreas SchusterPublished in: ESC heart failure (2023)
MF is associated with adverse CV outcome following TAVR, which is most prevalent in low EF situations. In the presence of large MF burden, patients with large AVC have better outcome following TAVR. Conversely, worse outcome in large MF and relatively little AVC may be explained by a relative prominence of an underlying cardiomyopathy. The better survival rates in large AVC patients following TAVR indicate TAVR induced relief of severe AS-associated pressure overload with subsequently improved outcome.
Keyphrases
- transcatheter aortic valve replacement
- aortic valve
- aortic stenosis
- transcatheter aortic valve implantation
- ejection fraction
- aortic valve replacement
- end stage renal disease
- chronic kidney disease
- left ventricular
- early onset
- peritoneal dialysis
- risk factors
- oxidative stress
- newly diagnosed
- high glucose
- diabetic rats
- endothelial cells
- patient reported