Glycolipid-peptide conjugate vaccines elicit CD8 + T-cell responses and prevent breast cancer metastasis.

Olivia K BurnKathryn FarrandTara PritchardSarah DraperChing-Wen TangAnna H MooneyAlfonso J SchmidtSung H YangGeoffrey M WilliamsMargaret A BrimbleMatheswaran KandasamyAndrew J MarshallKate ClarkeGavin F PainterIan F HermansRobert Weinkove

Published in: Clinical & translational immunology (2022)

Glycolipid-peptide conjugate vaccines that activate NKT cells prevent lung metastasis in breast cancer models and warrant investigation as adjuvant therapies for high-risk breast cancer.

Keyphrases

induced apoptosis
early stage
cancer therapy
cell cycle arrest
drug delivery