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BMSC-derived exosomal miR-219-5p alleviates ferroptosis in neuronal cells caused by spinal cord injury via the UBE2Z/NRF2 pathway.
Junjie Dong
Zhiqiang Gong
Hangchuan Bi
Jin Yang
Bing Wang
Kaili Du
Chunqiang Zhang
Lingqiang Chen
Published in:
Neuroscience (2024)
miR-219-5p in BMSC-derived exosomes can repair the injured spinal cord. In addition, miR-219-5p alleviates ferroptosis in neuronal cells induced by SCI through the UBE2Z/NRF2 pathway.
Keyphrases
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spinal cord injury
spinal cord
induced apoptosis
cell cycle arrest
cell death
oxidative stress
neuropathic pain
stem cells
endoplasmic reticulum stress
mouse model
bone marrow