Leukopenia, neutropenia, and procalcitonin levels in young febrile infants with invasive bacterial infections.

Andrew T KrackMichelle EckerlePrashant MahajanOctavio RamiloJohn M VanBurenRussell K BanksT Charles CasperDavid SchnadowerNathan Kuppermannnull null

Published in: Academic emergency medicine : official journal of the Society for Academic Emergency Medicine (2024)

Leukopenia ≤2500 cells/μL in febrile infants ≤60 days old is associated with IBIs. However, in the presence of normal PCT levels, no patients with leukopenia had IBIs. While this suggests leukopenia ≤2500 cells/μL is a risk factor for IBIs in non-critically ill young febrile infants only when PCT is unavailable or elevated, the overall low frequency of leukopenia in this cohort warrants caution in interpretation, with future validation required.

Keyphrases

induced apoptosis
cell cycle arrest
chemotherapy induced
urinary tract infection
endoplasmic reticulum stress
signaling pathway
oxidative stress
middle aged
cell death
cell proliferation