Association Between Brain Substructure Dose and Cognitive Outcomes in Children With Medulloblastoma Treated on SJMB03: A Step Toward Substructure-Informed Planning.

Sahaja Acharya Yian Guo Tushar PatniYimei LiChuang WangMelissa GargoneJason M AshfordLydia J WilsonAustin FaughtWilburn E ReddickZoltan PatayAmar J Gajjar Heather M Conklin Thomas E Merchant

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)

Increasing RT dose to the CC or frontal WM and hippocampus is associated with worse performance on tests of processing speed and associative memory, respectively. Brain substructure-informed RT planning may mitigate neurocognitive impairment.

Keyphrases

resting state
functional connectivity
white matter
cerebral ischemia
working memory
young adults
type diabetes
multiple sclerosis
skeletal muscle