RPB5-Mediating Protein Promotes Cholangiocarcinoma Tumorigenesis and Drug Resistance by Competing With NRF2 for KEAP1 Binding.

Zheng-Hua WanTian-Yi JiangYuan-Yuan ShiYu-Fei PanYun-Kai LinYun-Han MaChun YangXiao-Fan FengLi-Feng HuangXiao-Ni KongZhi-Wen DingYe-Xiong TanLi-Wei DongHong-Yang Wang

Published in: Hepatology (Baltimore, Md.) (2020)

These findings reveal that RMP is involved in the oxidative stress defense program and could be exploited for targeted cancer therapies.

Keyphrases

oxidative stress
protein protein
papillary thyroid
squamous cell
dna damage
binding protein
diabetic rats
genome wide
ischemia reperfusion injury
cancer therapy
induced apoptosis
small molecule
single cell
amino acid
gene expression
dna binding
drug delivery
childhood cancer
heat shock protein